Unfoldomics of Human Genetic Diseases
نویسندگان
چکیده
منابع مشابه
Unfoldomics of human genetic diseases: illustrative examples of ordered and intrinsically disordered members of the human diseasome.
Intrinsically disordered proteins (IDPs) constitute a recently recognized realm of atypical biologically active proteins that lack stable structure under physiological conditions, but are commonly involved in such crucial cellular processes as regulation, recognition, signaling and control. IDPs are very common among proteins associated with various diseases. Recently, we performed a systematic...
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1Center for Experimental Medicine and Department of Neurology, TheThird Xiangya Hospital, Central South University, Changsha 410013, China 2Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, 97080 Wurzburg, Germany 3Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School o...
متن کاملstem cells application in modeling of human genetic diseases
the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.1594